ORIE 5217

Designing and Running Personalized Health Experiments

Course Description

Course information provided by the 2026-2027 Catalog.

Traditionally, treatment guidelines and health recommendations are based on large cohort studies or randomized controlled trials (RCTs), which provide only average effect estimates. This limits their ability to predict whether an intervention will benefit an individual. With the rise of digital solutions, personalized approaches like N-of-1 trials are gaining traction. These modern designs allow for individual treatment effects and improve population-level effect estimates. This seminar covers N-of-1 trials and other modern study designs such as micro-randomized trials. First, we will get an overview of different study types and their characteristics, then we will give an introduction of the practical aspects for performing N-of-1 trials, and then the main focus of the class will be on methodological approaches for planning and analyzing N-of-1 trials.

Enrollment Information Enrollment limited to: Cornell Tech students.

Last 4 Terms Offered 2025SP

Learning Outcomes

• Understand the main concepts of planning & conducting N-of-1 trials and selected other study designs.
• Perform individual-level and aggregated analysis of N-of-1 trials using state-of-the-art methods.

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