TOX 7130

Cell Cycle Analysis

Course Description

Course information provided by the Courses of Study 2019-2020.

Presents a brief historical review of the cell cycle; a summary of cell-cycle regulatory processes; and practical methods for cell-cycle analysis, including mathematical representations. Topics include growth control of bacterial cell cycle including chemostats, mammalian-cell tissue culture, cell synchronization, flow cytometry, age-density representation, G1 regulation, labile regulatory protein models, cell transformation, regulation by growth factors and the cytoskeleton, cyclin/E2F/RB regulatory model, practical examples for analysis of cell-cycle phase durations, cell-cycle phase specific growth factor sensitivity, and timing of RB protein phosphorylation within the cell cycle. The objective of the course is to present graduate students with methods for cell-cycle analyses that will be used in their research.

When Offered Spring (offered alternate years).

Permission Note Enrollment limited to: 5 students.

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