BIOAP 4000

Cancer Genetics and Epigenetics

Course Description

Course information provided by the 2026-2027 Catalog.

This course explores how genetic and epigenetic mechanisms shape cancer development, progression, and therapeutic response. Students will examine somatic and germline mutations, chromosomal rearrangements, and regulatory variants that drive oncogenic transcriptional programs, as well as epigenetic alterations such as DNA methylation, histone modification, and chromatin reorganization. Through a modular framework spanning cancer genomics, epigenetics, and systems biology, the course integrates insights from molecular biology, metabolism, evolution, and the tumor microenvironment. Lectures, guest presentations, and problem-based exercises emphasize the experimental and computational tools that define modern cancer research and precision medicine.

Prerequisites Cell biology (BIOMG 1350 or equivalent), Genetics (BIOMG 2800 or equivalent), Biochemistry (BIOMG 3300 or equivalent).

Distribution Requirements (BSC-AG, MQL-AG)

Last 4 Terms Offered (None)

Learning Outcomes

• Explain how DNA mutations, chromatin states, and regulatory networks influence tumor initiation and progression, demonstrating understanding of key principles in the life sciences. (Assessed by class participation, midterms, and final exam)
• Interpret findings from primary research articles in cancer genomics and epigenomics, explaining the experimental approaches used and the biological significance of key results. (Assessed by in-class discussion, Slack channel engagement, midterms, and final exam)
• Apply data literacy and analytical reasoning to interpret results from genomic and epigenomic studies (e.g., mutation profiles, methylation patterns, enhancer maps) and draw defensible biological inferences. (Assessed by midterms and final exam)
• Communicate complex biological concepts and data interpretations clearly and effectively through written, oral, and visual formats for peers, instructors, and TAs. (Assessed by Slack channel participation, midterms, and final exam)
• Develop and evaluate mechanistic hypotheses connecting genetic and epigenetic mechanisms to cancer phenotypes, integrating information from molecular, cellular, and systems-level perspectives. (Assessed by midterms and final exam).

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