BME 5110

Stem Cell Bioengineering

Course Description

Course information provided by the Courses of Study 2024-2025.

This course explores the interface of stem cell biology and bioengineering and biotechnology and will examine the how quantitative modeling and analysis approaches inform stem cell-based biotechnologies and medical therapies. The course will cover embryonic and adult stem cell biology fundamentals, cell and molecular bioengineering concepts and techniques, biomolecular and genetic therapies to regulate stem cell function, and design of biomimetic and bioreactor environments for stem cell differentiation and derivation. These concepts will be conveyed in a mixture of assigned readings; interactive lectures; quantitative, descriptive, and computational problem sets; primary literature discussions and reviews; quizzes; and a small-team final grant proposal project.

When Offered Fall.

Prerequisites/Corequisites Prerequisite: BME 3010 and BME 3020, or equivalent.

Comments Computational programming experience in Matlab or similar language strongly encouraged.

• To identify key features of adult and pluripotent stem cell systems.
• To summarize molecular and cell engineering techniques to modulate stem cell functions.
• To design bioengineering strategies for enhancing stem cell-based regenerative medicine therapies.
• To analyze scientific publications for critical assessment of research methods, experimental design, and statistical/quantitative outcomes.
• To produce teaching modules on stem cell biology and revise/refine them for real-world dissemination.

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